We are privileged to have access to the following data resources powering our research.
Massachusetts Eye and Ear Dataset: We have demographic and clinical information for 1.69 million patients, 1.91 million fundus photos from 67,000 patients, 900,000 Zeiss Cirrus optical coherence tomography scans from 85,000 patients, 1.65 million Helderberg Spectralis optical coherence tomography scans from 73,000 patients, and 450,000 visual fields from 78,000 patients.
Glaucoma Research Network Dataset: We have 602,000 24-2 visual fields from 129,000 patients and 54,000 10-2 visual fields from 12,000 patients. The Glaucoma Research Network comprises data from Massachusetts Eye and Ear at Harvard Medical School, the Wilmer Eye Institute at Johns Hopkins University, the New York Eye and Ear Infirmary at the Icahn School of Medicine at Mount Sinai, the Bascom Palmer Eye Institute at the University of Miami, the Wills Eye Hospital at Thomas Jefferson University, and the Edward S. Harkness Eye Institute at Columbia University.
LIFE Dataset: We have data from 10,000 patients at baseline and 2,000 patients at 5-year follow-up from the LIFE-Adult Study randomly selected participants from 550,000 residents in Leipzig, which is a population-based cohort study conducted by the Leipzig Research Centre for Civilization Diseases (LIFE), University of Leipzig in Germany. All participants underwent fundus photography and optical coherence tomography examination, in addition to an extensive core assessment including physical examinations, cognitive function tests, genetic data, biospecimen tests, structured interviews, questionnaires, brain magnetic resonance imaging scans, etc.
American Academy of Ophthalmology IRIS Registry Dataset: The American Academy of Ophthalmology IRIS Registry (Intelligent Research in Sight) is the nation’s first EHR-based comprehensive eye disease and condition clinical registry and is also the world’s largest clinical data registry. As of May 2021, the IRIS Registry had participation from over 14,000 ophthalmologists and their 3,300 employed optometrists and included approximately 400 million patient encounters from about 70 million unique patients. Its reach continues to grow, providing ophthalmologists with clinical benchmarks and practice patterns. The Academy developed it as part of the profession’s shared goal of continual improvement in the delivery of eye care. Massachusetts Eye and Ear is one of the four institutions having full access to the entire dataset.
UK Biobank Dataset: We have data from 68,000 patients at baseline and 19,000 patients at follow-up with fundus photos, optical coherence tomography scans, physical examinations, cognitive function tests, genetic data, biospecimen tests, self-reported health conditions, ICD codes, brain, cardiac and abdominal magnetic resonance imaging scans, dual-energy X-ray absorptiometry scans, carotid ultrasound scans, etc. We get the UK Biobank data by paying an access fee.
Mass General Brigham Biobank Dataset: We have genomic and blood biomarker data from over 145,000 patients with their corresponding clinical records. The genomic data includes genotyping data, whole-genome sequencing data, exome sequencing data, gene expression data, and miRNA-Seq data.